What is Profhilo and How Does It Rejuvenate the Skin?
Profhilo is a hyaluronic acid (HA)–based treatment. At first glance, it may seem similar to dermal fillers, but it doesn’t belong in the filler category used for volumizing or contouring the face. What makes Profhilo unique is its hybrid HA structure, specially designed to remodel and restore the skin from within.
It works by stimulating various skin cells to naturally repair and regenerate tissue. This includes activation of keratinocytes (in the epidermis) and fibroblasts (in the dermis), leading to the production of collagen types I, III, IV, and VII, as well as increased elastin—without triggering inflammation. Additionally, it improves the quality of adipocytes (fat cells), helping the skin look younger, more hydrated, dewy, and radiant.
In short, unlike fillers that reshape facial contours, Profhilo stands out because of its structural HA properties that improve skin quality at multiple layers.
Unlike traditional fillers designed to add volume, the hyaluronic acid (HA) in Profhilo is formulated specifically for bio-remodeling—a structural skin rejuvenation approach that stimulates the natural production of collagen and elastin.
Profhilo contains two types of HA molecules: 32 mg of low molecular weight HA and 32 mg of high molecular weight HA. These are bonded together using a thermal process—without any chemical cross-linking agents—through a patented technology by IBSA known as NAHYCO® Hybrid Technology. This process results in a highly concentrated HA formulation (64 mg), which is twice as concentrated as most facial contouring fillers.
Thanks to this unique formulation, Profhilo remains in the skin longer while still dispersing evenly, similar to skin-rejuvenating fillers, but without forming lumps. Because no chemical cross-linkers (like BDDE) are used, Profhilo is exceptionally pure and free from synthetic additives. This purity minimizes the risk of inflammation and vascular occlusion, making Profhilo safe for use not only on the face, but also on delicate areas like the neck and body.
How Profhilo Works Beneath the Skin
Once injected, Profhilo spreads smoothly across the skin layers and stimulates four key types of skin cells:
Keratinocytes (epidermal cells): Help accelerate cell turnover, leaving the skin brighter and more radiant.
Fibroblasts (collagen-producing cells): Boost collagen production in the deeper dermal layers.
Adipocytes (fat cells): Support the skin’s natural volume, giving it a youthful, “baby fat” fullness.
Myocytes (muscle cells): Improve the strength and firmness of underlying facial muscles, helping to lift and tighten sagging skin.
In summary, Profhilo goes beyond superficial hydration. It helps repair and rejuvenate the skin’s internal structure, resulting in skin that is elastic, resilient, and healthier overall—making it a compelling option for those who want naturally youthful skin.
This rejuvenating effect is made possible by NAHYCO® Technology, which fuses high and low molecular weight hyaluronic acid (HA) into a Hybrid Cooperative Complex (HCC). This allows the HA to spread evenly in the skin without forming lumps, resulting in minimal swelling or bruising. The outcome? Hydrated, plump, smooth, and firm skin.
The Technology Behind Profhilo: What Makes It Different
Profhilo’s standout feature is its use of NAHYCO® Technology, which combines low and high molecular weight HA through a patented thermal process—no chemical cross-linking involved. This results in a new form of HA called Hybrid Cooperative Complex (HCC), designed to restore the skin’s structure across all layers.
- Superior Skin Diffusion: The HCC structure allows the active ingredients to spread evenly across the skin, improving hydration and supporting deep-layer skin remodeling.
- Collagen & Elastin Stimulation: NAHYCO® Technology enhances fibroblast activity, promoting the natural production of collagen and elastin for firmer, more elastic skin.
- No Chemical Cross-Linkers: Unlike traditional fillers that use chemical cross-linkers like BDDE to bind HA molecules, Profhilo uses only heat. This minimizes the risk of irritation, allergic reactions, or vascular complications.
What Can Profhilo Help With Compared to Other Treatments?
- Deep skin structure rejuvenation
- Stimulates collagen production up to 12 times more than standard HA treatments
- Activates fibroblast cells to accelerate skin regeneration
- Provides intense hydration with high-concentration HA
- Improves skin firmness and moisture retention
- Strengthens and restores the skin barrier for healthier-looking skin
- Reduces sagging and enhances skin elasticity
- Does not cause facial swelling or distortion
Who Is Profhilo Suitable For?
Profhilo is ideal for individuals who:
- Have dehydrated, dull, or dry skin that struggles to retain moisture
- Are starting to see early signs of fine lines and want to tighten skin texture
- Experience mild to moderate skin laxity or sagging
- Have large pores, acne scars, or uneven skin texture
- Want to rejuvenate skin health without altering facial structure
- Have previously undergone filler or Sculptra treatments and want to smooth the superficial skin layer
- Are aged 25 and up and looking to proactively slow down skin aging
Cost and Treatment Frequency for Best Results
The cost of Profhilo in Thailand may vary depending on the clinic and seasonal promotions. However, the average market price is approximately THB 3x,xxx per syringe.
Each Profhilo syringe contains 2 cc, and typically 2 to 4 cc in total is enough, depending on individual skin condition.
Recommended treatment protocol:
- 2 sessions spaced 1 month apart (1 syringe per session)
- For those with more severe skin concerns such as acne scars or deeper skin damage, a third session may be suggested to enhance collagen stimulation and achieve more visible improvements.
How Soon Can You See Results After Profhilo? How Long Does It Last? Can It Be Repeated?
- Visible within 7–14 days: Skin starts to feel more hydrated and appear brighter
- Full effect in 1–2 months: Improved elasticity, moisture, and smoothness; fine lines gradually diminish
- Results last 6–12 months: Depending on individual skin condition and lifestyle
- Recommended repeat every 6 months to maintain results and continue collagen stimulation
How to Care for Your Skin After Profhilo Injections to Maximize Results
To ensure long-lasting and visible outcomes after Profhilo treatment, follow these aftercare tips:
- Avoid touching or applying pressure to the treated area during the first 24 hours to reduce infection risk and irritation
- Avoid high heat exposure (e.g., saunas, hot showers, intense workouts) for the first week
- Refrain from using irritating skincare products such as AHA/BHA or retinol for at least 7 days
- Focus on hydrating the skin with a suitable moisturizer and drink plenty of water to enhance HA performance
- Always apply broad-spectrum sunscreen daily to protect collagen and elastin from UV damage
- Attend follow-up appointments with your doctor to assess the outcome and plan future treatments
Choosing a Safe and Trusted Clinic for Profhilo Injections
Selecting the right clinic is essential to ensure safe procedures and optimal results. Here’s what to look for:
1. Licensed and Authorized Facility
- ✅ Certified by Thailand’s Ministry of Public Health
- ✅ Clean, sterile treatment rooms following medical hygiene standards
2. Qualified and Experienced Doctors
- ✅ Must hold a valid medical license
- ✅ Preferably specialized in dermatology or aesthetic medicine
- ✅ Experienced specifically in injecting Profhilo
- ✅ Able to clearly explain treatment steps, results, and precautions
3. 100% Authentic Profhilo Product
- ✅ Packaging must include lot numbers and traceable import information
- ✅ Officially imported from IBSA Farmaceutici Italia
- ✅ You should be allowed to inspect the packaging before injection
- ✅ Check for the Thai FDA registration number on the box
4. Standardized Injection Techniques and Safety Measures
- ✅ Clinic uses the BAP (Bio Aesthetic Points) technique for optimal distribution
- ✅ Fresh, sterilized needles and equipment used for every session
- ✅ Clinic follows infection prevention protocols (gloves, masks, sterilization)
5. Verified Patient Reviews and Clinic Reputation
- ✅ Look for real before-and-after photos or video testimonials
- ✅ Choose a clinic with a strong reputation and no history of counterfeit use
- ✅ Ensure there are clear communication channels (website, phone, social media)
Summary: Your Profhilo Clinic Checklist
✔️ Ministry of Health certification and valid operating license
✔️ Licensed doctor with experience in Profhilo treatments
✔️ 100% genuine Profhilo with verifiable FDA registration
✔️ Standardized injection techniques (e.g., BAP technique)
✔️ Sterile, new equipment and safe injection practices
✔️ Real user reviews and trustworthy clinic reputation
By checking these six key points, you can feel confident and safe when choosing a Profhilo provider—and expect the best results 😊
